OverviewAPPLICATION CLOSING DATE : September 15th, 2025The Bienko Group at Human Technopole (HT) invites outstanding candidates with expertise in NGS bioinformatics and a strong interest in 3D genome biology and cancer genomics, to apply for a position as a Bioinformatician / Sr. Bioinformatician.HT is an interdisciplinary research institute created and supported by the Italian government, aiming to promote human health and healthy aging through genomics, computational biology, structural biology, neuroscience and health data science. HT operates National Facilities to provide technologies, methods and tools to the national scientific community.About the lab: The Bienko Group focuses on understanding how chromatin is spatially organized in the nucleus of mammalian cells and how 3D genome structure is affected by genomic rearrangements, such as those seen in human cancers.Essentially, the group seeks to advance knowledge of how 3D genome architecture relates to gene expression in the context of chromosomal translocations and other rearrangements.ResponsibilitiesImplement, maintain, and apply state-of-the-art pipelines and software for processing Hi-C, WGS (short- and long-read), RNA-seq, CUT&Tag, and BLISS data.Call somatic copy number alterations (SCNAs) and structural variants (SVs) by integrating WGS and Hi-C data; call A/B compartments, TADs, and chromatin loops from Hi-C data.Perform peak calling from CUT&Tag data and gene expression quantification, transcript isoform mapping, and gene set enrichment analyses.Engage in multi-omic data integration, including comparisons with public datasets (e.g., ENCODE, TCGA).Maintain and update the lab’s GitHub repositories.Apply rigorous statistical methods to study relationships between linear genome sequence, 3D genome structure, epigenome, and transcriptome.Propose and implement innovative methods for analyzing and visualizing rich datasets.Curate dataset deposition in public repositories (e.g., ENA or SRA).Collaborate with experimentalists to advise on experimental design, provide feedback on data quality, and offer internal workshops explaining analytical tools and results.Produce plots and participate in writing manuscripts describing analysis results.QualificationsEssential requirementsM.Sc. degree in Quantitative Biology, Biotechnology, Bioengineering, Genomic Sciences, or equivalent; candidates with M.Sc. in Computer Science, Mathematics or Physics who are eager to learn biology are welcome.Fluency in Bash, Python or R.Problem-solving orientation and proactive, forward-looking mindset.Strong collaborative attitude and ability to work in a team, brainstorming and solving challenging problems with others.Willingness to work with experimentalists who may not have a strong background in bioinformatics, and to explain computational methods clearly.Fluency in written and spoken English.Preferential requirementsExperience analyzing data generated by Hi-C (and derivatives), ChIP-seq, CUT&RUN / CUT&Tag, ATAC-seq, (sc)RNA-seq, WGS / WES, as demonstrated in publications or theses.Why Human TechnopoleHT seeks scientific excellence and recruits the best talents through international, open calls. The environment is international, friendly, and inclusive, encouraging collaboration across disciplines on biomedical topics and leveraging diverse skill sets.We believe diverse teams yield the best and most innovative results, and we engage in outward-facing scientific activities benefiting the research community. Training is a core activity, with opportunities for scientific courses, conferences, and workshops.Main benefitsWelfare plans.Meal delivery.Work-life balance provisions.Italian language training for foreigners.Parental leave up to 1 year and other support for new parents.Flexible working hours.Remote working policy.Relocation support.Attractive income tax benefits for researchers coming to Italy or returning after residence abroad.Special consideration will be given to candidates who are part of protected categories (L. 68/99).Number of positions offered : 1Salary range : up to 48k, depending on the seniority of the candidate.Contract offered : CCNL Chimico Farmaceutico, Fixed-term 3 years - employee level.The position is based in Milan.Funded by the European Union (ERC, RADIALIS, GA n. 101088408)
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