IRCCS San Raffaele Scientific Institute in Milan, Italy, is looking for a highly motivated Postdoctoral Fellow to join the Liver Gene Therapy Unit, SR-Tiget. The goal of our lab is to study liver dynamics during growth and homeostasis to devise permanent in vivo genetic engineering of hepatocytes for the treatment of metabolic diseases in pediatric patients. To this aim, we combine single-cell, organoids, and multiomic analyses, including the latest-generation spatial transcriptomics, together with advanced genetic engineering tools. The ERC-funded project builds on our recent findings that most hepatocytes are quiescent during liver growth, and only a fraction of them generate most of the adult tissue (Milani, Starinieri et al., J Hepatol 2025 https : / / tinyurl.com / 2x2nnf4r). We aim now to characterize molecular programs of mouse and human proliferating and quiescent hepatocyte subsets and assess their susceptibility to in vivo lentiviral gene delivery and targeted genome editing.
Main activities

Characterization of molecular and functional heterogeneity of hepatocytes during liver growth
In vivo genetic modification of hepatocytes
Data analysis and critical interpretation of the results
Discussion of project results at internal and external meetings

Training of younger fellows in the lab
Training of younger fellows in the lab.
Who we are looking for

Ph.D. in life sciences
Proven track record of publications in recognized journals
Documented experience in molecular and cellular biology
Previous experience with mouse models or gene therapy is a plus

Work details

Type of contract: renewable collaboration
Duration: 2 years
Place of work: IRCCS San Raffaele Hospital, Via Olgettina, number 60 - Milan (Italy)

At San Raffaele Scientific Institute, a world-renowned center of excellence for clinical and scientific activities, we believe that considering diversity and promoting an open and inclusive environment is crucial to our success. We are committed to ensure that equal employment opportunities are provided and based on merit without regard to age, religion, sex, disability, medical condition, sexual orientation, cultural and social backgrounds, gender identity or expression, national or ethnic origin, or any other legally recognized status entitled to protection under applicable laws. We offer attractive conditions and rewards appropriate to an internationally competitive research organization.
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