We are looking for a Pharmacology Scientist on behalf of an R&D company based near Milano.The candidates need to have expertise in AAV-based gene therapy and Cellular Biology.Main responsibilities :Prepares and maintains cell cultures (including primary cell cultures), perform studies and experiments including tissue processing, biochemical analyses, DNA, RNA and protein isolation, qRT-PCR, ELISA, immunoblot processing.Collaborate with cross-functional teams on planning in vitro and vivo screening campaigns in human osteoarthritis (OA) tissues and animal OA models.Develop, implement and execute in vitro screening assays, including binding assays and AAV transduction readouts in relevant cell lines.Perform bioanalysis for in vitro and in vivo studies to validate lead candidate capsidsCollaborate with cross-functional teams on vector design, production, and payload optimization for developing engineered tissue-tropic AAV capsid variants.
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