IRCCS San Raffaele Scientific Institute in Milan, Italy, is looking for a highly motivated Bioinformatician to join the Liver Gene Therapy Unit, SR‑Tiget. The goal of our lab is to study liver dynamics during growth and homeostasis to devise permanent in‑vivo genetic engineering of hepatocytes for the treatment of metabolic diseases in pediatric patients. To this aim, we combine single‑cell, organoids, and multi‑omic analyses, including the latest‑generation spatial transcriptomics, together with advanced genetic engineering tools. The ERC‑funded project builds on our recent findings that most hepatocytes are quiescent during liver growth, and only a fraction of them generate most of the adult tissue (Milani, Starinieri et al., J Hepatol 2025 https://tinyurl.com/2x2nnf4r). We aim now to characterise molecular programmes of mouse and human proliferating and quiescent hepatocyte subsets and assess their susceptibility to in‑vivo lentiviral gene delivery and targeted genome editing.
Main responsibilities

Analysis of a variety of NGS datasets, including RNA‑Seq, scRNA‑Seq, ChIP‑seq, and spatial transcriptomics
Full integration within the SR‑TIGET Bioinformatics Core and the Center for Omics Sciences (COSR) at the San Raffaele Scientific Institute
Critical interpretation of the results
Discussion of project results at internal and external meetings

Who we are looking for
We are seeking a proactive and self‑driven candidate with a Ph.D. and scientific background in one or more of the following fields: Bioinformatics, Biotechnology, Computer Science, Computer Engineering, or Biomedical Engineering.
The ideal candidate will have:

A solid foundation in Next‑Generation Sequencing (NGS) data analysis
Proven experience with established bioinformatic and biostatistical tools (e.g., R, Bioconductor)
Proficiency in programming languages such as Python and Bash
Interest in developing new computational methods to study the biology of hepatocytes
Experience with single‑cell and spatial transcriptomics analysis is a plus, though not required

Work details

Type of contract: renewable fixed‑term contract ("a tempo determinato")
Duration: 1 year
Place of work: IRCCS San Raffaele Hospital, Via Olgettina, number 60 - Milan (Italy)

At San Raffaele Scientific Institute, a world‑renowned centre of excellence for clinical and scientific activities, we believe that considering diversity and promoting an open and inclusive environment is crucial to our success. We are committed to ensure that equal employment opportunities are provided and based on merit without regard to age, religion, sex, disability, medical condition, sexual orientation, cultural and social backgrounds, gender identity or expression, national or ethnic origin, or any other legally recognised status entitled to protection under applicable laws. We offer attractive conditions and rewards appropriate to an internationally competitive research organisation.
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