Job DescriptionJob DescriptionArrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.The PositionThis position will involve assisting in the synthesis and subsequent purification steps of large scale oligonucleotides. The operator must comply with GLP/GMP protocols and be able to follow all association SOPs and work instructions when performing and documenting operations.ResponsibilitiesPrepare batch records, SOPs, and work instructions to detailDocument alloperations in batch records and notebooksExperience in investigating and closing deviationsAbility to identify, design, and implement process improvementsComply with GMP protocolsOperate large scale oligonucleotide manufacturing equipment (i.e. oligonucleotide synthesizer, purification skid, tangential flow filtration system, lyophilizer, ChemGlass reactors, pH/conductivity meters, peristaltic pumps, )Lead and provide support to other chemists within the CMC group during synthesis and purification of oligonucleotides including:Reagent solution preparationMobile phase preparationColumn PackingFraction collectionDevelop and optimize test methods for oligonucleotide/intermediate analysis via LCMSAssist in scale up/process development from small/mid-scale chemistryContact vendors for purchasing manufacturing equipment/performing routine maintenance and repair, and assist with FATs for equipment as neededMaintain a clean work spaceMaintain safety by wearing required personal protective equipmentMaintain safety by wearing required personal protective equipmentTrack and update raw material usage in D365 ERP softwareAct as production campaign leadAssist with new personnel trainingAddress and resolve production challenges proactively, utilizing analytical and critical thinking skillsRequirements:Bachelors degree in a scientific field5-10 years experience in a similar positionExperience working in a GMP setting and controlled documentationAbility to move and lift up to 50 poundsGood verbal and written communication skillsAbility to work in a team environmentAbility to pay attention to detailWisconsin pay range $78,000—$90,000 USDArrowhead provides competitive salaries and an excellent benefit package.All applicants must have authorization to work in the US for a company.California Applicant Privacy Policy
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